The Akhtar lab uses a combination of mouse and human models to investigate the mechanistic and physiological functions of the H4K16-specific histone acetyltransferase MOF/KAT8. MOF associates with two distinct protein complexes, the NSL complex and the MSL complex, which in turn regulate its substrate specificity, genomewide targeting and physiological functions. The lab has a long-standing interest in understanding the cell- and tissue-specific functions of the NSL and MSL complexes at both molecular and physiological levels, including dissecting how MOF influences cell fate and development decisions. This is particularly pertinent given that mutations in MOF and in several MSL and NSL complex members (KANSL1, MSL2, MSL3) are associated with human neurodevelopmental disorders. Furthermore, the lab has shown that the NSL complex is a key regulator of mitochondrial metabolism.

The lab utilizes a combination of in vivo mouse models as well as in vitro culture of primary cells and in vitro differentiation of mouse ESCs and human iPSCs into different cell lineages as well as organoids. The recruited postdoc will contribute towards this line of research by studying MOF in one or more cell types, tissues or 2D or 3D model systems of interest. 

Qualifications:

•           Applicants should have a PhD in molecular biology, biochemistry, genetics, bioinformatics and/or high-resolution imaging

•           Prior experience working with mouse models and/or with 2D or 3D systems based on in vitro differentiation of mouse embryonic stem cells or human induced pluripotent stem cells is required

•           Candidates should have at least one first-author publication

•           The ability to work in a team, communication skills and experience in the supervision of graduate students are assets