The Akhtar lab explores the diversity of functions of epigenetic factors, with a particular interest in the histone acetyltransferase MOF and the MOF-associated NSL and MSL complexes in flies and mammals.

We are looking for an ambitious, highly-motivated, science-driven and experienced bioinformatics postdoc to join our team to unravel the molecular mechanisms by which these epigenetic factors regulate gene expression. You will work closely together with wet lab scientists in the design, analysis and interpretation of NGS experiments relevant to your project.

The lab generates large quantities of deep sequencing datasets, including bulk and single-cell RNA-seq, ChIP-seq (including CUT&RUN, CUT&Tag and RELACS), bulk and single-cell ATAC-seq, scMultiome, bisulfite sequencing, chromatin conformation (including Hi-C and Micro-C) and Nanopore long-read sequencing, which we analyse using a combination of adaptation of existing bioinformatic tools and development of new analysis tools. Members of the lab have also contributed to the deepTools2 suite (Ramírez et al 2016 Nucleic Acids Research) and snakePipes package (Bhardwaj et al 2019 Bioinformatics) developed by the bioinformatics facility at our institute headed by Dr. Thomas Manke.

Qualifications:

• Applicants should either have a PhD degree in bioinformatics / computer science or a PhD degree in biology of which bioinformatic analysis was a major component
• Proficiency in programming in R and/or Python, UNIX/shell scripts as well as the ability to build new tailored pipelines are prerequisites for this position
• Candidates should have at least 2 years of proven experience in analyses of OMICS data (such as ChIP-seq, RNA-seq, ATAC-seq, bisulfite sequencing)
• Candidates must have a strong publication record and possess excellent communication skills
• Candidates must be able to demonstrate the ability to collaborate with colleagues and work well in a team