The oyster mushroom (Pleurotus ostreatus), a widely studied edible fungus, harbors a remarkable secret: it is a carnivorous predator capable of paralyzing and digesting nematodes to supplement its nutrient uptake. This predatory behavior hinges on a specialized structure called the toxocyst, which delivers a volatile neurotoxic compound to disrupt nematode nervous systems, enabling their capture and digestion (Lee et al., Science Advances). Recent unbiased genetic screens have identified approximately 20 genes critical to toxocyst development, yet their specific roles and the molecular mechanisms underlying this evolutionary adaptation remain largely unknown. 

We are seeking a highly motivated postdoctoral researcher to join our team in dissecting the functional roles of these genes and the regulatory mechanisms to elucidate the molecular pathways governing toxocyst biogenesis in P. ostreatus. By bridging mycology, molecular biology, and evolutionary genomics, this work aims to reveal the genetic basis of fungal carnivory and its ecological significance, with potential implications for biocontrol applications targeting nematode pests. Candidates with strong background in molecular biology, cell biology, genetics, or lipid biochemistry are ideal. Strong collaborative skills are essential for success in this interdisciplinary team.