The Mateus group pursues interdisciplinary experimental research at the interface of quantitative (developmental and cell) biology, biochemistry, genetics, and physics. Our goal is to understand how size and shape affect function across scales, from organs to organelles.
We are looking for a motivated and independent wet-lab scientist who is interested in collaboratively working in the context of our awarded HFSP project, MetaCrystal: Metabolic principles of intracellular crystallization.
This exploratory and interdisciplinary project is being pursued together with the laboratories of Noemi Jimenez-Rojo (University of Basque Country, Spain) and Viviana Monje (SUNY, University at Buffalo, USA) with the aim of disentangling the dynamic relationship between organellar membranes, intracellular crystallization and crystal growth. For this, we are using zebrafish iridophores as an experimental model, since these cells concentrate high amounts of purines in membrane-bound organelles, the iridosomes, for controlled crystallization. Here, crystals assemble into unusually large, flat, and thin hexagons following unknown mechanisms that evolve against thermodynamically favorable interactions.