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Details of the postdoctoral positions
Application Round
September 2025
Project title
Membrane Control of Biogenic Crystallization
City
Dresden
Specific field of research
Biochemistry, Structural Biology, Chemical Biology, Biophysics
Cell and Developmental Biology, Genetics
Max Planck Institute
Max Planck Institute of Molecular Cell Biology and Genetics
Broad field of research
Biology & Medicine Section
Short description of the group/project/topic of research

The Mateus group pursues interdisciplinary experimental research at the interface of quantitative (developmental and cell) biology, biochemistry, genetics, and physics. Our goal is to understand how size and shape affect function across scales, from organs to organelles.

We are looking for a motivated and independent wet-lab scientist who is interested in collaboratively working in the context of our awarded HFSP project, MetaCrystal: Metabolic principles of intracellular crystallization.

This exploratory and interdisciplinary project is being pursued together with the laboratories of Noemi Jimenez-Rojo (University of Basque Country, Spain) and Viviana Monje (SUNY, University at Buffalo, USA) with the aim of disentangling the dynamic relationship between organellar membranes, intracellular crystallization and crystal growth. For this, we are using zebrafish iridophores as an experimental model, since these cells concentrate high amounts of purines in membrane-bound organelles, the iridosomes, for controlled crystallization. Here, crystals assemble into unusually large, flat, and thin hexagons following unknown mechanisms that evolve against thermodynamically favorable interactions.

Additional information

As a key team member, you will:

  • Implement organellar biochemistry studies on zebrafish iridosome extraction, purification, and proteomic profiling.
  • Generate genetically manipulated zebrafish for omics validation using CRISPR/Cas9 technology, as well as assess respective protein subcellular localization dynamics.
  • Jointly work with other team members to establish primary cell cultures for diverse zebrafish iridophore types, genetic backgrounds, and developmental stages.

Your qualifications:

  • PhD in biology, chemistry, life sciences or related discipline
  • Strong communication skills, a collaborative mindset, and English proficiency
  • High degree of responsibility, perseverance, and ownership
  • Critical thinking and problem-solving skills
  • Prior exposure to mass spectrometry and/or protein biochemistry, Python-based programming (or similar languages), and/or expansion microscopy would be advantageous.

Our offer:

  • We offer a diversified job in a young, scientifically oriented, international team in one of the most renowned research institutions worldwide.
  • The full-time position is available for an initial period of 3 years, starting as soon as possible.
  • Salary is according to TVöD Bund, E13 based on qualifications and experience.
  • Conditions and social benefits of the public service, including 30 days’ vacation, annual special payment, comprehensive insurance, and an attractive pension plan via VBL (Federal and State Government Employees' Retirement Fund)
  • Discounted job ticket (VVO) and good public transport connections
  • Positive work-life balance, including assistance with family and childcare matters
  • A broad network for career development and training through the Max Planck Society

The Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the Center for Systems Biology Dresden (CSBD) are basic research institutes that foster collaborations between theorists and experimentalists. Currently about 500 employees from over 50 countries work at the institute in a highly collaborative and curiosity-driven environment. Our research programs are interdisciplinary and span multiple scales of magnitude, from molecular assemblies to organelles, cells, tissues, organs, and organisms. As an employer, MPI-CBG offers an environment that fosters open communication and collaboration, an environment with equal opportunities and support for families. The official language of the institute is English.

For further information regarding the scientific tasks, please contact Dr. Rita Mateus (mateus@mpi-cbg.de). For initial inquiries regarding employment conditions, please contact Brian von Rueden, Head of Human Resources (hr@mpi-cbg.de).

Requirements
Requirements

Applicants have to upload their 

  • CV (including a publication list)
  • a summary of previous research
  • and a statement of interest
Additional requirements for the application
  • names and contact information for 2 potential references
Principal Investigator
Rita Mateus - Max Planck Institute of Molecular Cell Biology and Genetics
Email: mateus@mpi-cbg.de
Contact person
Rita Mateus
mateus@mpi-cbg.de
+49 351 210-2504